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Found 3 Enz. Inhib. hit(s) with Target = 'Gonadotropin-releasing hormone receptor' and Ligand = 'BDBM50213657'
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213657((S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(6-fluoro-1H...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213657((S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(6-fluoro-1H...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human GnRHR expressed in RBL cells assessed as inhibition of GnRH-stimulated [3H]-inositol phosphate hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213657((S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(6-fluoro-1H...)
Affinity DataIC50:  28nMAssay Description:Inhibition of GnRHR in rat pituitary cells assessed as inhibition of GnRH-stimulated LH releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed