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Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' and Ligand = 'BDBM50440890'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440890
PNG
(CHEMBL2431841 | US9066954, 341)
Show SMILES Cn1cc(cn1)-c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C19H15N7/c1-25-12-15(11-21-25)17-6-7-18-22-23-19(26(18)24-17)10-13-4-5-16-14(9-13)3-2-8-20-16/h2-9,11-12H,10H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
9.10 -46.2n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440890
PNG
(CHEMBL2431841 | US9066954, 341)
Show SMILES Cn1cc(cn1)-c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C19H15N7/c1-25-12-15(11-21-25)17-6-7-18-22-23-19(26(18)24-17)10-13-4-5-16-14(9-13)3-2-8-20-16/h2-9,11-12H,10H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
74n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440890
PNG
(CHEMBL2431841 | US9066954, 341)
Show SMILES Cn1cc(cn1)-c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C19H15N7/c1-25-12-15(11-21-25)17-6-7-18-22-23-19(26(18)24-17)10-13-4-5-16-14(9-13)3-2-8-20-16/h2-9,11-12H,10H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 44n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440890
PNG
(CHEMBL2431841 | US9066954, 341)
Show SMILES Cn1cc(cn1)-c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C19H15N7/c1-25-12-15(11-21-25)17-6-7-18-22-23-19(26(18)24-17)10-13-4-5-16-14(9-13)3-2-8-20-16/h2-9,11-12H,10H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 69n/an/an/an/an/an/a



Hutchison MediPharma Limited

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human NCI-H441 cells for 1 hr by ELISA


J Med Chem 57: 7577-89 (2014)


Article DOI: 10.1021/jm500510f
BindingDB Entry DOI: 10.7270/Q2JD4ZCR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440890
PNG
(CHEMBL2431841 | US9066954, 341)
Show SMILES Cn1cc(cn1)-c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C19H15N7/c1-25-12-15(11-21-25)17-6-7-18-22-23-19(26(18)24-17)10-13-4-5-16-14(9-13)3-2-8-20-16/h2-9,11-12H,10H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 210n/an/an/an/an/an/a



Hutchison MediPharma Limited

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using Poly E4Y substrate and ATP incubated for 45 mins by fluorescence polarization assay


J Med Chem 57: 7577-89 (2014)


Article DOI: 10.1021/jm500510f
BindingDB Entry DOI: 10.7270/Q2JD4ZCR
More data for this
Ligand-Target Pair