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Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone chaperone ASF1A' and Ligand = 'BDBM50101679'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone chaperone ASF1A


(Homo sapiens)
BDBM50101679
PNG
(CHEMBL3394919)
Show SMILES O=C(N\N=C\c1ccccn1)c1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C20H16N4O2/c25-19(15-6-2-1-3-7-15)23-17-11-9-16(10-12-17)20(26)24-22-14-18-8-4-5-13-21-18/h1-14H,(H,23,25)(H,24,26)/b22-14+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 5.50E+4n/an/an/an/an/an/a



Colorado Center for Drug Discovery, Colorado State University, Department of Chemistry, Fort Collins, CO 80523-1872, USA. Electronic address: Greg.Miknis@Colostate.edu.

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human Asf1a binding with H3/H4 assessed as fluorescence intensity after 30 mins by ALPHA assay


Bioorg Med Chem Lett 25: 963-8 (2015)

More data for this
Ligand-Target Pair