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Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone chaperone ASF1A' and Ligand = 'BDBM50101688'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone chaperone ASF1A


(Homo sapiens)
BDBM50101688
PNG
(CHEMBL3394910)
Show SMILES COc1cc(\C=N\NC(=O)c2ccc(NC(=O)c3ccccc3)cc2)cc(OC)c1O
Show InChI InChI=1S/C23H21N3O5/c1-30-19-12-15(13-20(31-2)21(19)27)14-24-26-23(29)17-8-10-18(11-9-17)25-22(28)16-6-4-3-5-7-16/h3-14,27H,1-2H3,(H,25,28)(H,26,29)/b24-14+
PDB

UniProtKB/SwissProt

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AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.00E+4n/an/an/an/an/an/a



Colorado Center for Drug Discovery, Colorado State University, Department of Chemistry, Fort Collins, CO 80523-1872, USA. Electronic address: Greg.Miknis@Colostate.edu.

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human Asf1a binding with H3/H4 assessed as fluorescence intensity after 30 mins by ALPHA assay


Bioorg Med Chem Lett 25: 963-8 (2015)

More data for this
Ligand-Target Pair