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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone chaperone ASF1A' and Ligand = 'BDBM50101708'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone chaperone ASF1A


(Homo sapiens)
BDBM50101708
PNG
(CHEMBL3394903)
Show SMILES COc1ccc(cc1)C(=O)Nc1ccc(cc1)C(=O)N\N=C\c1cc(Br)c(O)c(OC)c1
Show InChI InChI=1S/C23H20BrN3O5/c1-31-18-9-5-15(6-10-18)22(29)26-17-7-3-16(4-8-17)23(30)27-25-13-14-11-19(24)21(28)20(12-14)32-2/h3-13,28H,1-2H3,(H,26,29)(H,27,30)/b25-13+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 4.50E+4n/an/an/an/an/an/a



Colorado Center for Drug Discovery, Colorado State University, Department of Chemistry, Fort Collins, CO 80523-1872, USA. Electronic address: Greg.Miknis@Colostate.edu.

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human Asf1a binding with H3/H4 assessed as fluorescence intensity after 30 mins by ALPHA assay


Bioorg Med Chem Lett 25: 963-8 (2015)

More data for this
Ligand-Target Pair