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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone chaperone ASF1A' and Ligand = 'BDBM50101742'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone chaperone ASF1A


(Homo sapiens)
BDBM50101742
PNG
(CHEMBL3394895)
Show SMILES CCCCC(=O)Nc1ccc(cc1)C(=O)N\N=C\c1cc(Br)c(O)c(OC)c1
Show InChI InChI=1S/C20H22BrN3O4/c1-3-4-5-18(25)23-15-8-6-14(7-9-15)20(27)24-22-12-13-10-16(21)19(26)17(11-13)28-2/h6-12,26H,3-5H2,1-2H3,(H,23,25)(H,24,27)/b22-12+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.40E+4n/an/an/an/an/an/a



Colorado Center for Drug Discovery, Colorado State University, Department of Chemistry, Fort Collins, CO 80523-1872, USA. Electronic address: Greg.Miknis@Colostate.edu.

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human Asf1a binding with H3/H4 assessed as fluorescence intensity after 30 mins by ALPHA assay


Bioorg Med Chem Lett 25: 963-8 (2015)

More data for this
Ligand-Target Pair