Compile Data Set for Download or QSAR
Found 3 Enz. Inhib. hit(s) with Target = 'Interleukin-1 receptor-associated kinase 4' and Ligand = 'BDBM294283'
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM294283(US9586948, Example 2)
Show SMILES Cn1cc(NC(=O)c2cccc(n2)-n2cccc2)c(n1)C(N)=O
Show InChI InChI=1S/C15H14N6O2/c1-20-9-11(13(19-20)14(16)22)18-15(23)10-5-4-6-12(17-10)21-7-2-3-8-21/h2-9H,1H3,(H2,16,22)(H,18,23)
Affinity DataIC50: 649nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM294283(US9586948, Example 2)
Show SMILES Cn1cc(NC(=O)c2cccc(n2)-n2cccc2)c(n1)C(N)=O
Show InChI InChI=1S/C15H14N6O2/c1-20-9-11(13(19-20)14(16)22)18-15(23)10-5-4-6-12(17-10)21-7-2-3-8-21/h2-9H,1H3,(H2,16,22)(H,18,23)
Affinity DataIC50: 653nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged full-length IRAK4 expressed in baculovirus infected Sf9 insect cells using 5FAM-RKRQGSVRRRVH-CO...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM294283(US9586948, Example 2)
Show SMILES Cn1cc(NC(=O)c2cccc(n2)-n2cccc2)c(n1)C(N)=O
Show InChI InChI=1S/C15H14N6O2/c1-20-9-11(13(19-20)14(16)22)18-15(23)10-5-4-6-12(17-10)21-7-2-3-8-21/h2-9H,1H3,(H2,16,22)(H,18,23)
Affinity DataIC50: 653nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged full-length IRAK4 expressed in baculovirus infected Sf9 insect cells using 5FAM-RKRQGSVRRRVH-CO...More data for this Ligand-Target Pair