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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Leucyl-cystinyl aminopeptidase' and Ligand = 'BDBM271258'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271258
PNG
(US10059720, Example 73)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H34N2O4/c1-13(2)9-19(22)21(26,20(24)25)11-16-10-18(15(4)12-23-16)27-17-7-5-14(3)6-8-17/h10,12-14,17,19,26H,5-9,11,22H2,1-4H3,(H,24,25)/t14-,17-,19-,21+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271258
PNG
(US10059720, Example 73)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H34N2O4/c1-13(2)9-19(22)21(26,20(24)25)11-16-10-18(15(4)12-23-16)27-17-7-5-14(3)6-8-17/h10,12-14,17,19,26H,5-9,11,22H2,1-4H3,(H,24,25)/t14-,17-,19-,21+/m0/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair