BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'MAP kinase ERK2' and Ligand = 'BDBM204272'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase ERK2


(Homo sapiens (human))
BDBM204272
PNG
(US9242996, 346)
Show SMILES Nc1ncc(nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(I)c2)c(F)c1)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C25H26FIN4O3/c26-20-11-16(23-24(28)29-12-21(30-23)14-4-7-18(33)8-5-14)6-9-19(20)25(34)31-22(13-32)15-2-1-3-17(27)10-15/h1-3,6,9-12,14,18,22,32-33H,4-5,7-8,13H2,(H2,28,29)(H,31,34)/t14-,18-,22-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0175n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...


Citation and Details
More data for this
Ligand-Target Pair