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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'MDM2 and p53' and Ligand = 'BDBM215165'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MDM2 and p53


(Homo sapiens (Human))
BDBM215165
PNG
(US9296736, 116 | US9593129, Example 116)
Show SMILES C[C@@]1(CC(O)=O)C[C@@H](C(N(C(C2CC2)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1/C27H29Cl2NO3/c1-27(15-23(31)32)14-22(19-3-2-4-21(29)13-19)25(18-9-11-20(28)12-10-18)30(26(27)33)24(16-5-6-16)17-7-8-17/h2-4,9-13,16-17,22,24-25H,5-8,14-15H2,1H3,(H,31,32)/t22-,25?,27+/s2
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 390n/an/an/an/a7.425



Amgen Inc

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair