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Found 2 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' and Ligand = 'BDBM50154979'
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50154979(2-{2-[4-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl}...)
Affinity DataKi:  633nMAssay Description:Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50154979(2-{2-[4-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl}...)
Affinity DataIC50:  737nMAssay Description:Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed