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Found 25 Enz. Inhib. hit(s) with Target = 'Monoglyceride lipase' and Ligand = 'BDBM60622'
TargetMonoglyceride lipase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human MAGL expressed in COS7 cells using endogenous 2-AG substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human MAGL expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of recombinant human MAGL using fluorogenic-7HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Mus musculus (mouse))
University Of M£Nster

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  6nMAssay Description:Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brain membranes preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human MGLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Mus musculus (mouse))
University Of M£Nster

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  6nMAssay Description:Inhibition of MAGL in mouse brain membrane using 2-AG as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  6nMAssay Description:Inhibition of MAGL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant MAGL expressed in Cos7 cells after 30 mins by using 2-AG as a substrate by LC-MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Mus musculus (mouse))
University Of M£Nster

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  8nMAssay Description:Inhibition of MAGL in C57B1/6J mouse brain membrane after 30 mins by using 2-AG as a substrate by LC-MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Mus musculus (mouse))
University Of M£Nster

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  8nMAssay Description:Inhibition of mouse MAGLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Mus musculus (mouse))
University Of M£Nster

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  8nMAssay Description:Inhibition of mouse recombinant MAGL expressed in african green monkey COS7 cells assessed as inhibition of 2-AG hydrolysis after 30 mins by LC-MS an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant MAGL (unknown origin) expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Mus musculus (mouse))
University Of M£Nster

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  10nMAssay Description:Inhibition of MAGL in mouse brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  10nMAssay Description:Inhibition of MAGLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  20nMAssay Description:The compounds II-2a to II-2m and controls in Table II were tested in 10-dose IC50 mode, with 3-fold serial dilution at a starting concentration of 10...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMonoglyceride lipase(Rattus norvegicus (Rat))
University Of M£Nster

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  25nMAssay Description:Inhibition of rat MAGL expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human MAGL assessed as [3H]-2-OG hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  48nMAssay Description:Inhibition of human recombinant MAGL using 4-NPA substrate incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  49nMAssay Description:Inhibition of human recombinant MAGL using 4-NPA as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  57nMAssay Description:Inhibition of human N-terminal histidine tagged full length MAGL expressed in Escherichia coli by by coumarin ester substrate fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  285nMAssay Description:Inhibition of recombinant C-terminal His6-tagged human MAGL expressed in Escherichia coli using 2-arachidonoyl-[3H]-glycerol as substrate incubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  520nMAssay Description:Inhibition of human recombinant MAGLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human His-tagged MAGL assessed as formation of arachidonic acid using 2-acylglycerol incubated for 10 mins by mass spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human recombinant MAGL-mediated 1,3-dihydroxypropan-1-yl 4-pyren-1-ylbutanoate conversion to 4-pyren-1-ylbutanoic acid preincubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  4.44E+3nMAssay Description:Inhibition of recombinant C-terminal His6-tagged human MAGL expressed in Escherichia coli using 2-arachidonoyl-[3H]-glycerol as substrate preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed