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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Muscarinic receptor M1 and M2' and Ligand = 'BDBM50003358'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic receptor M1 and M2


(RAT)
BDBM50003358
PNG
(5-(4-Chloro-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3...)
Show SMILES CN1CCC=C(C1)c1nsnc1Cl
Show InChI InChI=1S/C8H10ClN3S/c1-12-4-2-3-6(5-12)7-8(9)11-13-10-7/h3H,2,4-5H2,1H3
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Novo Nordisk CNS Division

Curated by ChEMBL


Assay Description
In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-oxotremorine-M (Oxo-M) as radioligand


J Med Chem 35: 2274-83 (1992)


Article DOI: 10.1021/jm00090a019
BindingDB Entry DOI: 10.7270/Q22J69TH
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50003358
PNG
(5-(4-Chloro-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3...)
Show SMILES CN1CCC=C(C1)c1nsnc1Cl
Show InChI InChI=1S/C8H10ClN3S/c1-12-4-2-3-6(5-12)7-8(9)11-13-10-7/h3H,2,4-5H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 375n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat hippocampus M1 receptor using [3H]-pirenzepine (Pz) as radioligand


J Med Chem 35: 4011-9 (1992)


Article DOI: 10.1021/jm00100a005
BindingDB Entry DOI: 10.7270/Q2KW5F1K
More data for this
Ligand-Target Pair