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Found 18 Enz. Inhib. hit(s) with Target = 'Neuropeptide Y receptor type 1' and Ligand = 'BDBM50246649'
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataKi:  0.0370nMAssay Description:Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]propionyl-pNPY from NPY1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataKi:  0.420nMAssay Description:Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50:  0.0501nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50:  0.0501nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50:  0.0631nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50:  0.126nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50:  0.151nMAssay Description:Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50:  0.170nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye base...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50:  0.427nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye base...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50:  0.708nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50:  2.80nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50:  8.20nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed