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Found 9 Enz. Inhib. hit(s) with Target = 'Nicotinamide phosphoribosyltransferase' and Ligand = 'BDBM50438936'
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50438936(CHEMBL2420629 | GNE-617)
Affinity DataIC50:  2nMAssay Description:Inhibition of NAMPT in human A2780 cells assessed as decrease in cell viability after 72 hrs by SRB assayMore data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50438936(CHEMBL2420629 | GNE-617)
Affinity DataIC50:  5nMAssay Description:Inhibition of C-terminal His-tagged NAMPT (unknown origin) expressed in Escherichia coli BL21 using nicotinamide as substrate preincubated for 15 min...More data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50438936(CHEMBL2420629 | GNE-617)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:The reaction was carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well plates. NAMPT protein was added to 1 B...More data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50438936(CHEMBL2420629 | GNE-617)
Affinity DataIC50:  5nMAssay Description:Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal...More data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50438936(CHEMBL2420629 | GNE-617)
Affinity DataIC50:  5nMAssay Description:Inhibition of human full length C-terminal His6-tagged NAMPT expressed in Escherichia coli Rosetta (DE3) cells using nicotinamide as substrate incuba...More data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Rattus norvegicus)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50438936(CHEMBL2420629 | GNE-617)
Affinity DataIC50:  23nMAssay Description:Inhibition of rat NAMPT after 30 mins by mass spectrometry-based analysisMore data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Mus musculus)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50438936(CHEMBL2420629 | GNE-617)
Affinity DataIC50:  24nMAssay Description:Inhibition of mouse NAMPT after 30 mins by mass spectrometry-based analysisMore data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50438936(CHEMBL2420629 | GNE-617)
Affinity DataEC50:  1.10nMAssay Description:Inhibition of NAMPT in human PC3 cells assessed as reduction in NAD level after 48 hrs by mass spectrometryMore data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Mus musculus)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50438936(CHEMBL2420629 | GNE-617)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of NAMPT in mouse cells assessed as reduction in NAD level after 48 hrs by mass spectrometryMore data for this Ligand-Target Pair