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Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform' and Ligand = 'BDBM122452'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122452
PNG
(US8729074, 9)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)N1CCOCC1
Show InChI InChI=1S/C22H19ClFN5O3S/c23-22-19(27-33(30,31)18-4-1-16(24)2-5-18)11-15(12-26-22)20-13-25-21-6-3-17(14-29(20)21)28-7-9-32-10-8-28/h1-6,11-14,27H,7-10H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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PC cid
PC sid
UniChem

Similars

US Patent
4n/a 6n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair