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Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform' and Ligand = 'BDBM122468'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122468
PNG
(US8729074, 18)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1ccncc1
Show InChI InChI=1S/C19H17ClN6O2S/c1-25(2)29(27,28)24-16-9-15(10-23-19(16)20)17-11-22-18-4-3-14(12-26(17)18)13-5-7-21-8-6-13/h3-12,24H,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
1n/an/an/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair