BindingDB PrimarySearch

Found 23 Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform' and Ligand = 'BDBM50403068'

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 120nMAssay Description:Inhibition of PI3K p110beta (unknown origin) using lipid substrate after 40 mins by kinase-Glo assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 129nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using Biotin-S11S12 as substrate after 60 mins in presence of ATP by ADPGlo luminescence assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 134nMAssay Description:Inhibition of PI3K beta (unknown origin) using lipid substrate measured after 40 mins in presence of ATP by Kinase-Glo plus reagent based luminescenc...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 139nMAssay Description:Inhibition of PI3K beta (unknown origin) using phosphatidyl inositol as substrate measured after 60 mins in presence of ATP by Kinase-Glo Plus reagen...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 154nMAssay Description:Inhibition of His6-tagged recombinant full length human N-terminal PI3Kbeta expressed in baculovirus infected Sf21 cells using lipid substrate incuba...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 198nMMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 380nMAssay Description:Inhibition of PI3Kbeta (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 380nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: >500nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 562nMAssay Description:Inhibition of PI3K p110beta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 564nMAssay Description:Inhibition of recombinant full-length human His-tagged PI3Kbeta expressed in insect cells by Selectscreen kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 565nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate incubated for 1 hr in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 565nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 565nMAssay Description:Inhibition of recombinant human His-tagged PI3Kbeta expressed in insect cell expression system using PIP2:PS as substrate incubated for 1 hr by invit...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 571nMAssay Description:Inhibition of human PI3Kbeta using PIP2 as substrate after 1 hrMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 613nMAssay Description:Inhibition of recombinant human full length His-tagged p110beta expressed in baculovirus expression system measured after 60 mins in presence of ATP ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 669nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 846nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2:PS as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr in pr...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 1.40E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) by biochemical Alphascreen assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 2.00E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using biotin-PIP3 as substrate preincubated for 15 mins followed by substrate addition and measured after 60 ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 2.47E+3nMAssay Description:Inhibition of PI3Kbeta in human 786-0 cells assessed as reduction in AKT phosphorylation at S473 residue incubated for 30 minsMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 4.00E+3nMAssay Description:Inhibition of His-tagged recombinant human PIK3CBMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Filter my 23 hits

Targets 1▿
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 23
Publications 19▿
- Eur J Med Chem 125: 1156-1171 (2017) 2
- J Med Chem 62: 10402-10422 (2019) 2
- Bioorg Med Chem Lett 30: (2020) 2
- Bioorg Med Chem 45: (2021) 1
- J Med Chem 64: 8951-8970 (2021) 1
- Bioorg Med Chem 27: (2019) 1
- J Med Chem 65: 3849-3865 (2022) 1
- J Med Chem 64: 12304-12321 (2021) 1
- Eur J Med Chem 170: 112-125 (2019) 1
- Eur J Med Chem 156: 831-846 (2018) 1
- J Med Chem 63: 441-469 (2020) 1
- J Med Chem 56: 1922-39 (2013) 1
- Bioorg Med Chem Lett 29: 1313-1319 (2019) 1
- Bioorg Med Chem 26: 2028-2040 (2018) 1
- Eur J Med Chem 151: 9-17 (2018) 1
- Bioorg Med Chem Lett 27: 2849-2853 (2017) 1
- Bioorg Med Chem 27: (2019) 1
- J Med Chem 60: 5193-5208 (2017) 1
- Bioorg Med Chem Lett 25: 1104-9 (2015) 1
Institutions 15▿
- Xi'An Jiaotong University 3
- Bristol-Myers Squibb 2
- Shanghai Institute Of Materia Medica (Simm) 2
- University Of Nottingham 2
- Zhejiang University 2
- Southwest Jiaotong University 2
- The University Of Arizona 1
- Novartis Institutes For Biomedical Research 1
- Amgen 1
- Zydus Research Centre 1
- Chinese Academy Of Sciences 1
- University Of Arkansas For Medical Sciences 1
- National Clinical Research Center For Geriatrics 1
- Shandong University 1
- Sungkyunkwan University 1
Affinity: 1.2E+2 to 4.0E+3 nM▿
- IC50 23
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1