BindingDB PrimarySearch_ki

Found 28 Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform' and Ligand = 'BDBM50403068'

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 27nMAssay Description:Inhibition of recombinant human full length His-tagged p110gamma expressed in baculovirus expression system measured after 60 mins in presence of ATP...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 51nMAssay Description:Inhibition of PI3Kgamma (unknown origin) measured by ADP-Glo assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 63nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 63nMAssay Description:Inhibition of PI3Kgamma (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 63nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 63nMAssay Description:Inhibition of His-tagged recombinant human full length PI3K p110gamma expressed in baculovirus expression system using lipid substrate incubated for ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 67nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2:PS as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr in p...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 89nMAssay Description:Inhibition of PI3K p110gamma (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 89nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 89nMAssay Description:Inhibition of recombinant full-length human His-tagged PI3Kgamma expressed in baculovirus expression system by Selectscreen kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 89nMAssay Description:Inhibition of recombinant human His-tagged PI3Kgamma expressed in baculovirus expression system using PIP2:PS as substrate incubated for 1 hr by invi...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 89nMAssay Description:Inhibition of PI3Kgamma in basophil derived from B-cell malignant patientMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 89nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate incubated for 1 hr in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 92nMAssay Description:Inhibition of human PI3Kgamma using PIP2 as substrate after 1 hrMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 104nMAssay Description:Inhibition of recombinant human full-length His-tagged PI3K p110gamma expressed in baculovirus expression system using PIP2 as substrate measured aft...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 139nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using Biotin-S11S12 as substrate after 60 mins in presence of ATP by ADPGlo luminescence assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 139nMAssay Description:Inhibition of PI3K p110gamma (unknown origin) using lipid substrate after 40 mins by kinase-Glo assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 145nMAssay Description:Inhibition of PI3K gamma (unknown origin) using phosphatidyl inositol as substrate measured after 60 mins in presence of ATP by Kinase-Glo Plus reage...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 200nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using biotin-PIP3 as substrate preincubated for 15 mins followed by substrate addition and measured after 60...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 200nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using biotin-PIP3 as substrate preincubated for 15 mins followed by substrate addition and measured after 60...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 241nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 245nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 250nMAssay Description:Inhibition of PI3KCgamma (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 381nMAssay Description:Inhibition of PI3K gamma (unknown origin) using lipid substrate measured after 40 mins in presence of ATP by Kinase-Glo plus reagent based luminescen...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 580nMAssay Description:Inhibition of PI3Kgamma (unknown origin) by biochemical Alphascreen assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Mus musculus (Mouse))
National Clinical Research Center For Geriatrics

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 1.30E+3nMAssay Description:Inhibition of PI3Kgamma in c5a-stimulated mouse RAW264.7 cells assessed as reduction in AKT phosphorylation at S473 residue incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 2.10E+3nMAssay Description:Inhibition of human full length PI3Kgamma using PIP2/ATP as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL

PNG

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)

IC50: 2.10E+3nMAssay Description:Inhibition of His-tagged recombinant human PIK3CG expressed in Baculovirus expression systemMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Filter my 28 hits

Targets 1▿
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 28
Publications 25▿
- Eur J Med Chem 125: 1156-1171 (2017) 2
- J Med Chem 62: 10402-10422 (2019) 2
- Bioorg Med Chem Lett 30: (2020) 2
- Bioorg Med Chem 45: (2021) 1
- J Med Chem 64: 8951-8970 (2021) 1
- Bioorg Med Chem 73: (2022) 1
- Bioorg Med Chem 27: (2019) 1
- J Med Chem 65: 3849-3865 (2022) 1
- J Med Chem 64: 12304-12321 (2021) 1
- Eur J Med Chem 170: 112-125 (2019) 1
- Eur J Med Chem 156: 831-846 (2018) 1
- J Med Chem 63: 441-469 (2020) 1
- J Med Chem 56: 1922-39 (2013) 1
- J Med Chem 62: 4783-4814 (2019) 1
- Bioorg Med Chem Lett 29: 1313-1319 (2019) 1
- J Med Chem 60: 1555-1567 (2017) 1
- J Med Chem 62: 4936-4948 (2019) 1
- Bioorg Med Chem 26: 2028-2040 (2018) 1
- Eur J Med Chem 151: 9-17 (2018) 1
- Eur J Med Chem 158: 405-413 (2018) 1
- Bioorg Med Chem Lett 27: 2849-2853 (2017) 1
- Bioorg Med Chem 27: (2019) 1
- J Med Chem 60: 5193-5208 (2017) 1
- Bioorg Med Chem Lett 25: 1104-9 (2015) 1
- Eur J Med Chem 163: 413-427 (2019) 1
Institutions 21▿
- Xi'An Jiaotong University 3
- Bristol-Myers Squibb 2
- Shanghai Institute Of Materia Medica (Simm) 2
- University Of Nottingham 2
- Zhejiang University 2
- Southwest Jiaotong University 2
- The University Of Arizona 1
- Amgen 1
- China Pharmaceutical University 1
- Chinese Academy Of Sciences 1
- Hutchison Medipharma 1
- University Of Arkansas For Medical Sciences 1
- National Clinical Research Center For Geriatrics 1
- Shandong University 1
- Sungkyunkwan University 1
- Novartis Institutes For Biomedical Research 1
- Zydus Research Centre 1
- Astrazeneca 1
- Gilead Sciences 1
- Inserm 1052/Cnrs 5286/University Of Lyon 1
- Anhui University Of Chinese Medicine 1
Affinity: 27 to 2.1E+3 nM▿
- IC50 28
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1