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Found 1 hit Enz. Inhib. hit(s) with Target = 'Platelet-derived growth factor receptor (PDGFr)' and Ligand = 'BDBM50191979'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50191979
PNG
(CHEMBL3906976)
Show SMILES Cc1ccc(cc1NC(=O)c1cnn2ccccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C23H20N4O2/c1-16-10-11-18(22(28)24-14-17-7-3-2-4-8-17)13-20(16)26-23(29)19-15-25-27-12-6-5-9-21(19)27/h2-13,15H,14H2,1H3,(H,24,28)(H,26,29)
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KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL


Assay Description
Inhibition of PDGFR-beta driven proliferation of rat A10 cells after 68 hrs in presence of rat recombinant PDGF-BB by cell titer-glo luminescence ass...


J Med Chem 59: 7901-14 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00703
BindingDB Entry DOI: 10.7270/Q25X2BW1
More data for this
Ligand-Target Pair