BindingDB PrimarySearch

Found 18 Enz. Inhib. hit(s) with Target = 'Platelet-derived growth factor receptor beta' and Ligand = 'BDBM16673'

Platelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 0.260nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair

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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 18.4nMT: 2°CAssay Description:Experimental Procedures(1) Kinase reaction substrate Poly(Glu, Tyr, 4:1) was diluted to 20 μg/ml with potassium ion-free PBS, and enzyme labeled pla...More data for this Ligand-Target Pair

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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 37nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair

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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 57nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair

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Platelet-derived growth factor receptor beta(Mus musculus (mouse))
Bayer Pharmaceuticals

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 57nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...More data for this Ligand-Target Pair

KEGG
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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 57nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 57nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 57nMAssay Description:Inhibition of PDGFRbeta kinaseMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 60nMAssay Description:Inhibition of PDGFR beta (unknown origin)More data for this Ligand-Target Pair

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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 90nMMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 130nMAssay Description:Inhibition of PDGFR-beta (unknown origin) by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 583nMAssay Description:Inhibition of PDGFRbeta (unknown origin) using TK substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

Kd: 37nMAssay Description:Binding affinity to PDGFRBMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

Kd: 41nMAssay Description:Inhibition of PDGFRbeta by cellular assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

Kd: 41nMAssay Description:Average Binding Constant for PDGFRB; NA=Not Active at 10 uMMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

Kd: 37nMAssay Description:Binding constant for PDGFRB kinase domainMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

Kd: 37nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

Kd: 37nMAssay Description:Binding constant for PDGFRB kinase domainMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Filter my 18 hits

Targets 1▿
- Platelet-derived growth factor receptor beta 18
Publications 17▿
- US Patent US9469639 (2016) 1
- J Med Chem 64: 11747-11773 (2021) 1
- Eur J Med Chem 163: 37-53 (2019) 1
- Blood 114: 2984-92 (2009) 1
- Nat Biotechnol 26: 127-32 (2008) 1
- Eur J Med Chem 179: 707-722 (2019) 1
- Proc Natl Acad Sci U S A 104: 19936-41 (2007) 1
- Cancer Res 64: 7099-109 (2004) 1
- Bioorg Med Chem 27: (2019) 1
- US Patent US11505527 (2022) 1
- J Med Chem 53: 1413-37 (2010) 1
- Nat Biotechnol 23: 329-36 (2005) 1
- Nat Chem Biol 2: 358-64 (2006) 1
- Nat Biotechnol 29: 1046-51 (2011) 1
- J Med Chem 64: 12022-12048 (2021) 1
- J Med Chem 55: 5749-59 (2012) 1
- PubChem Bioassay (2008) 1
Institutions 13▿
- Ambit Biosciences 5
- Schering-Plough 1
- Bayer Pharmaceuticals 1
- Novartis Research Foundation 1
- Beijing Normal University 1
- West China Hospital Of Sichuan University 1
- Radiant Pharma & Tech. 1
- Harvard Medical School 1
- University Of Arkansas For Medical Sciences 1
- Kafrelsheikh University 1
- National Research Centre 1
- National Institute Of Biological Sciences 1
- King Abdulaziz University 1
Affinity: 0.26 to 5.8E+2 nM▿
- IC50 12
- Kd 6
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1