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Found 4 Enz. Inhib. hit(s) with Target = 'Poly [ADP-ribose] polymerase 1' and Ligand = 'BDBM27088'
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM27088(1H-1,3-benzodiazole-4-carboxamide | 1H-benzimidazo...)
Affinity DataKi:  95nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM27088(1H-1,3-benzodiazole-4-carboxamide | 1H-benzimidazo...)
Affinity DataKi:  240nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM27088(1H-1,3-benzodiazole-4-carboxamide | 1H-benzimidazo...)
Affinity DataKi:  240nM ΔG°:  -37.4kJ/molepH: 8.0 T: 2°CAssay Description:PARP assays utilizing SPA bead-based detection were carried out in 96-well plates. After reaction was terminated, the reaction mixtures were transfer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM27088(1H-1,3-benzodiazole-4-carboxamide | 1H-benzimidazo...)
Affinity DataIC50:  240nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed