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Found 1 hit Enz. Inhib. hit(s) with Target = 'Poly [ADP-ribose] polymerase 1' and Ligand = 'BDBM50446671'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50446671
PNG
(CHEMBL3113565)
Show SMILES NC(=O)c1cccc2[nH]c(nc12)-c1ccc(OCCF)cc1
Show InChI InChI=1S/C16H14FN3O2/c17-8-9-22-11-6-4-10(5-7-11)16-19-13-3-1-2-12(15(18)21)14(13)20-16/h1-7H,8-9H2,(H2,18,21)(H,19,20)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Washington University in Saint Louis

Curated by ChEMBL


Assay Description
Inhibition of PARP-1 (unknown origin) assessed as NAD+ consumption after 20 mins by fluorometric analysis in presence of activated DNA


Bioorg Med Chem 22: 1700-7 (2014)


Article DOI: 10.1016/j.bmc.2014.01.019
BindingDB Entry DOI: 10.7270/Q2TX3GVH
More data for this
Ligand-Target Pair