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Found 2 Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM50477061'
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477061(CHEMBL393401)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477061(CHEMBL393401)
Affinity DataIC50:  4nMAssay Description:Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed