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Found 7 Enz. Inhib. hit(s) with Target = 'Prolyl endopeptidase' and Ligand = 'BDBM50051495'
TargetProlyl endopeptidase(Sus scrofa)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051495((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of poricne brain POP in expressed in Escherichia coli TOP10 competent cells pre-incubated for 2 hrs before Z-Gly-Pro-AMC substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051495((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Affinity DataKi:  0.0600nMAssay Description:Inhibitory activity against prolyl oligopeptidase of porcine brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051495((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Affinity DataIC50:  0.100nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051495((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against prolyl oligopeptidase of porcine brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051495((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of pig brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051495((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Affinity DataIC50:  0.200nMpH: 7.0Assay Description:In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051495((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Affinity DataIC50:  0.830nMAssay Description:Inhibition of POP in rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed