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Found 3 Enz. Inhib. hit(s) with Target = 'Purine nucleoside phosphorylase' and Ligand = 'BDBM22107'
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Industrial Research

LigandPNGBDBM22107(7-{[(2R,4R)-2,4-bis(hydroxymethyl)azetidin-1-yl]me...)
Affinity DataKi:  280nM ΔG°:  -37.0kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Industrial Research

LigandPNGBDBM22107(7-{[(2R,4R)-2,4-bis(hydroxymethyl)azetidin-1-yl]me...)
Affinity DataKi:  360nM ΔG°:  -36.4kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Plasmodium falciparum)
Industrial Research

LigandPNGBDBM22107(7-{[(2R,4R)-2,4-bis(hydroxymethyl)azetidin-1-yl]me...)
Affinity DataKi:  580nM ΔG°:  -35.2kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed