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Found 4 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase ATR' and Ligand = 'BDBM103467'
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM103467(US8552004, 2.03)
Affinity DataIC50:  5.61nMpH: 7.4 T: 2°CAssay Description:ATR for use in the in vitro enzyme assay was obtained from HeLa nuclear extract (CIL Biotech, Mons, Belgium) by immunoprecipitation with rabbit polyc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM103467(US8552004, 2.03)
Affinity DataIC50:  6nMAssay Description:Inhibition of ATR in human HeLa cell nuclear extract using GST-fused p53N66 as substrate preincubated for 10 mins followed by ATP addition and measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM103467(US8552004, 2.03)
Affinity DataIC50:  7.05nMAssay Description:ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM103467(US8552004, 2.03)
Affinity DataIC50:  9nMAssay Description:Inhibition of ATR in human HT29 cells after 60 mins by Hoechst 33258 staining-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed