BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase PLK1' and Ligand = 'BDBM50403011'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50403011
PNG
(CHEMBL2207840)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CCCNC(=O)CCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O |r|
Show InChI InChI=1S/C39H64N7O12P/c1-25(2)23-30(43-39(54)32-19-14-22-46(32)27(4)48)37(52)42-29(18-13-21-41-33(49)20-12-7-5-6-9-15-28-16-10-8-11-17-28)36(51)44-31(24-47)38(53)45-34(35(40)50)26(3)58-59(55,56)57/h8,10-11,16-17,25-26,29-32,34,47H,5-7,9,12-15,18-24H2,1-4H3,(H2,40,50)(H,41,49)(H,42,52)(H,43,54)(H,44,51)(H,45,53)(H2,55,56,57)/t26-,29+,30+,31+,32+,34+/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 170n/an/an/an/an/an/a



Frederick National Laboratory for Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to GFP-HA-fused PLK1 polo box domain expressed in HEK293A cells using biotinylated p-T38 peptide as substrate after 1 hr...


Bioorg Med Chem Lett 22: 7306-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.093
BindingDB Entry DOI: 10.7270/Q2Z89DK2
More data for this
Ligand-Target Pair