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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase PLK1' and Ligand = 'BDBM86320'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM86320
PNG
(Phosphodiester analog, 3a)
Show SMILES COP(O)(=O)O[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)C1CCCN1C(C)=O)C(N)=O
Show InChI InChI=1/C27H45N8O11P/c1-14(2)9-18(32-27(42)21-7-6-8-35(21)16(4)37)24(39)31-19(10-17-11-29-13-30-17)25(40)33-20(12-36)26(41)34-22(23(28)38)15(3)46-47(43,44)45-5/h11,13-15,18-22,36H,6-10,12H2,1-5H3,(H2,28,38)(H,29,30)(H,31,39)(H,32,42)(H,33,40)(H,34,41)(H,43,44)/t15-,18+,19+,20+,21?,22+/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.00E+5n/an/an/an/a8.025



National Cancer Institute-Frederick



Assay Description
The evaluation of Plk1 PBD binding affinities of the synthetic compounds using an ELISA-based 96-well assay.


Nat Chem Biol 7: 595-601 (2011)


Article DOI: 10.1038/nchembio.614
BindingDB Entry DOI: 10.7270/Q2CN72GB
More data for this
Ligand-Target Pair