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Found 4 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase Sgk1' and Ligand = 'BDBM50043783'
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM50043783(CHEMBL3356053 | US9174993, 46 | US9221828, 46)
Affinity DataIC50:  2nMAssay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM50043783(CHEMBL3356053 | US9174993, 46 | US9221828, 46)
Affinity DataIC50:  2nMAssay Description:Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM50043783(CHEMBL3356053 | US9174993, 46 | US9221828, 46)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The enzyme reaction was carried out in a buffer containing 25 mM Tris-HCl (pH 7.4), 5 mM MgCl2, 2 mM MnCl2, 2 mM DTT, and 0.03% bovine serum albumi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM50043783(CHEMBL3356053 | US9174993, 46 | US9221828, 46)
Affinity DataIC50:  40nMAssay Description:Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed