Found 25 Enz. Inhib. hit(s) with Target = 'Sphingosine 1-phosphate receptor 1' and Ligand = 'BDBM23165' 
Affinity DataKi: 2.10nM ΔG°: -46.0kJ/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 0.00800nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by radioligand competitive binding analy...More data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Agonist activity at human S1P1 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 EDG1 cells by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity at human S1P1 receptor expressed in RH7777 cells by [35S]GTP-gammaS accumulation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.280nMAssay Description:Induction of internalization of C-terminal GFP-fused human S1P1 receptor expressed in CHO cell membranes after 50 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0120nMAssay Description:Agonist activity at human S1P1 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.02nMAssay Description:Agonist activity at human S1P1 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.370nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.290nMAssay Description:Agonist activity at rat S1P1 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.290nMAssay Description:Agonist activity at rat S1P1 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 0.370nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 19.9nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 EDG1 cells expressing beta-arrestin 2 after 105 mins by chemi-luminiscence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at SIP1 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 7nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHOK1 cell membranes by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.00700nMAssay Description:Agonist activity at human recombinant S1P1 expressed in CHO cell membranes assessed as stimulation of cAMP accumulation incubated for 10 mins by HTRF...More data for this Ligand-Target Pair
Affinity DataEC50: 0.700nMAssay Description:Agonist activity at human recombinant S1P1 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0700nMAssay Description:Agonist activity at human recombinant C-terminal GFP-fused S1P1 expressed in CHO cells assessed as induction of receptor internalization incubated fo...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0200nMAssay Description:Agonist activity at human recombinant S1P1 expressed in CHO cells assessed as stimulation of ERK phosphorylation incubated for 7 mins by microplate r...More data for this Ligand-Target Pair
Affinity DataEC50: 0.400nMAssay Description:Agonist activity at human S1P1 receptor expressed in EDG1-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMpH: 7.4Assay Description:Agonism of human S1P-1 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 7nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHOK1 cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity at recombinant human S1P1 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.00600nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
