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Found 10 Enz. Inhib. hit(s) with Target = 'Synaptic vesicular amine transporter' and Ligand = 'BDBM50459625'
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50459625(CHEMBL4205254)
Affinity DataKi:  62nMAssay Description:Displacement of [3H]reserpine from human VMAT2 expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50459625(CHEMBL4205254)
Affinity DataKi:  62nMAssay Description:Displacement of [3H]reserpine from human VMAT2 expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50459625(CHEMBL4205254)
Affinity DataKi:  290nMAssay Description:Displacement of [3H](+)-syn-Ethyl 1-(2-(2,4-Dioxo-1,2-dihydroquinazolin-3(4H)-yl)ethyl)-4-(4-fluorophenyl)piperidine-3-carboxylate from human VMAT2 e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50459625(CHEMBL4205254)
Affinity DataKi:  7.80E+3nMAssay Description:Displacement of [3H]DHTB from human VMAT2 expressed in HEK293 cell membranes incubated for 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50459625(CHEMBL4205254)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]DHTB from human VMAT2 expressed in HEK293 cell membranes incubated for 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Mus musculus)
Organix

Curated by ChEMBL
LigandPNGBDBM50459625(CHEMBL4205254)
Affinity DataIC50:  3.39nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Mus musculus)
Organix

Curated by ChEMBL
LigandPNGBDBM50459625(CHEMBL4205254)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50459625(CHEMBL4205254)
Affinity DataIC50:  16nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50459625(CHEMBL4205254)
Affinity DataIC50:  16nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50459625(CHEMBL4205254)
Affinity DataKd:  93nMAssay Description:Displacement of [3H](+)-syn-Ethyl 1-(2-(2,4-Dioxo-1,2-dihydroquinazolin-3(4H)-yl)ethyl)-4-(4-fluorophenyl)piperidine-3-carboxylate from human VMAT2 e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed