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Found 3 Enz. Inhib. hit(s) with Target = 'TGF-beta receptor type-1' and Ligand = 'BDBM21509'
TargetTGF-beta receptor type-1(Homo sapiens (Human))TBA
LigandPNGBDBM21509(4-[2-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]...)
Affinity DataKi:  38nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTGF-beta receptor type-1(Homo sapiens (Human))TBA
LigandPNGBDBM21509(4-[2-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect cells after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))TBA
LigandPNGBDBM21509(4-[2-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]...)
Affinity DataIC50:  370nMAssay Description:Inhibition of TGFbetaR1 in human primary T-cells assessed as TGFbeta-stimulated PSMAD phosphorylation preincubated for 1 hr followed by TGFbeta addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed