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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'TGF-beta receptor type-1' and Ligand = 'BDBM50351816'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351816
PNG
(CHEMBL1824436)
Show SMILES Cc1cccc(n1)-c1c(cnn1CC(=O)Nc1cccc(c1)C#N)-c1ccc2nccnc2c1
Show InChI InChI=1S/C26H19N7O/c1-17-4-2-7-23(31-17)26-21(19-8-9-22-24(13-19)29-11-10-28-22)15-30-33(26)16-25(34)32-20-6-3-5-18(12-20)14-27/h2-13,15H,16H2,1H3,(H,32,34)
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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 737n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351816
PNG
(CHEMBL1824436)
Show SMILES Cc1cccc(n1)-c1c(cnn1CC(=O)Nc1cccc(c1)C#N)-c1ccc2nccnc2c1
Show InChI InChI=1S/C26H19N7O/c1-17-4-2-7-23(31-17)26-21(19-8-9-22-24(13-19)29-11-10-28-22)15-30-33(26)16-25(34)32-20-6-3-5-18(12-20)14-27/h2-13,15H,16H2,1H3,(H,32,34)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair