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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'TGF-beta receptor type-1' and Ligand = 'BDBM50351821'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351821
PNG
(CHEMBL1824441)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2ccccc2)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C27H24N6S/c1-17-8-7-11-24(28-17)27-22(20-12-13-23-25(14-20)30-19(3)18(2)29-23)15-33(32-27)16-26(34)31-21-9-5-4-6-10-21/h4-15H,16H2,1-3H3,(H,31,34)
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PC cid
PC sid
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Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351821
PNG
(CHEMBL1824441)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2ccccc2)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C27H24N6S/c1-17-8-7-11-24(28-17)27-22(20-12-13-23-25(14-20)30-19(3)18(2)29-23)15-33(32-27)16-26(34)31-21-9-5-4-6-10-21/h4-15H,16H2,1-3H3,(H,31,34)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair