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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Thrombopoietin receptor' and Ligand = 'BDBM50219625'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50219625
PNG
(CHEMBL247606 | N-(4-(2-fluoro-3-(trifluoromethoxy)...)
Show SMILES Fc1c(OC(F)(F)F)cccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5O2S/c22-18-14(2-1-3-16(18)32-21(23,24)25)15-10-33-20(29-15)30-19(31)12-4-6-13(7-5-12)28-17-8-9-26-11-27-17/h1-11H,(H,26,27,28)(H,29,30,31)
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UniProtKB/SwissProt

DrugBank
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 32n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219625
PNG
(CHEMBL247606 | N-(4-(2-fluoro-3-(trifluoromethoxy)...)
Show SMILES Fc1c(OC(F)(F)F)cccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5O2S/c22-18-14(2-1-3-16(18)32-21(23,24)25)15-10-33-20(29-15)30-19(31)12-4-6-13(7-5-12)28-17-8-9-26-11-27-17/h1-11H,(H,26,27,28)(H,29,30,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 32n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Bioorg Med Chem Lett 17: 5447-54 (2007)

More data for this
Ligand-Target Pair