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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Thrombopoietin receptor' and Ligand = 'BDBM50219659'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50219659
PNG
((Z)-N-(4-(3,4-difluorophenyl)thiazol-2-yl)-4-((2,4...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(cc1)C(=O)Nc1nc(cs1)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C20H11F2N3O3S2/c21-13-6-5-12(8-14(13)22)15-9-29-19(23-15)24-17(26)11-3-1-10(2-4-11)7-16-18(27)25-20(28)30-16/h1-9H,(H,23,24,26)(H,25,27,28)
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Article
PubMed
n/an/an/an/a 28n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Bioorg Med Chem Lett 17: 5447-54 (2007)

More data for this
Ligand-Target Pair