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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Thrombopoietin receptor' and Ligand = 'BDBM50248024'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50248024
PNG
(1-(3-bromo-5-(4-(2-fluoro-3-(trifluoromethyl)pheny...)
Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1Br)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H17BrF4N4O3S/c23-15-8-12(9-28-18(15)31-6-4-11(5-7-31)20(33)34)19(32)30-21-29-16(10-35-21)13-2-1-3-14(17(13)24)22(25,26)27/h1-3,8-11H,4-7H2,(H,33,34)(H,29,30,32)
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PC sid
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Similars

AffyNet 
Article
PubMed
n/an/an/an/a 50n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair