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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Thrombopoietin receptor' and Ligand = 'BDBM50263455'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50263455
PNG
(2-hydroxy-9-(4-propoxyphenyl)-6,11-dihydro-5H-benz...)
Show SMILES CCCOc1ccc(cc1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C26H23NO4/c1-2-11-31-18-7-3-15(4-8-18)16-5-9-19-20-10-6-17-12-22(26(29)30)24(28)14-21(17)25(20)27-23(19)13-16/h3-5,7-9,12-14,27-28H,2,6,10-11H2,1H3,(H,29,30)
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Article
PubMed
n/an/an/an/a 41n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Bioorg Med Chem Lett 18: 5255-8 (2008)

More data for this
Ligand-Target Pair