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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Thrombopoietin receptor' and Ligand = 'BDBM50325421'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50325421
PNG
(4-(2-(1-(5-fluoro-2-oxo-1-p-tolylindolin-3-ylidene...)
Show SMILES CC(=NNC(=S)c1ccc(cc1)C(O)=O)C1C(=O)N(c2ccc(F)cc12)c1ccc(C)cc1
Show InChI InChI=1S/C25H20FN3O3S/c1-14-3-10-19(11-4-14)29-21-12-9-18(26)13-20(21)22(24(29)30)15(2)27-28-23(33)16-5-7-17(8-6-16)25(31)32/h3-13,22H,1-2H3,(H,28,33)(H,31,32)
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Article
PubMed
n/an/an/an/a 44n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant TPO receptor expressed in mouse BaF3 cells after 24 hrs


Bioorg Med Chem Lett 20: 5062-4 (2010)

More data for this
Ligand-Target Pair