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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Transient receptor potential M8 protein' and Ligand = 'BDBM50380685'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380685
PNG
(CHEMBL2017500)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)cc1)c1cn(-c2ccccc2)c2ccc(Cl)cc12
Show InChI InChI=1S/C26H26ClFNO3P/c1-3-31-33(30,32-4-2)26(16-19-10-13-21(28)14-11-19)24-18-29(22-8-6-5-7-9-22)25-15-12-20(27)17-23(24)25/h5-15,17-18,26H,3-4,16H2,1-2H3
KEGG

UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair