Found 9 Enz. Inhib. hit(s) with Target = 'Trifunctional purine biosynthetic protein adenosine-3' and Ligand = 'BDBM22590'
Affinity DataKi: 0.000120nMAssay Description:Inhibitory activity against glycinamide ribonucleotide formyltransferase (GARFT) from L1210 murine leukemic cellsMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Hebei Medical University
Curated by ChEMBL
Hebei Medical University
Curated by ChEMBL
Affinity DataKi: 6nMAssay Description:Inhibition of GARFTase (unknown origin)More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Hebei Medical University
Curated by ChEMBL
Hebei Medical University
Curated by ChEMBL
Affinity DataKi: 60nM ΔG°: -41.4kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Hebei Medical University
Curated by ChEMBL
Hebei Medical University
Curated by ChEMBL
Affinity DataKi: 60nM ΔG°: -41.4kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
Affinity DataKi: 60nMAssay Description:Tested in vitro for its inhibition of trifunctional glycinamide ribonucleotide formyltransferase (GARFT) isolated from murine L1210 leukemia cellsMore data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Tested for the inhibition of trifunctional Glycinamide ribonucleotide formyltransferase isolated from murine L1210 cells.More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Hebei Medical University
Curated by ChEMBL
Hebei Medical University
Curated by ChEMBL
Affinity DataKi: 130nMAssay Description:Tested for the inhibition of recombinant human monofunctional Glycinamide ribonucleotide formyltransferaseMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Hebei Medical University
Curated by ChEMBL
Hebei Medical University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of incorporation of [14C]glycine into [14C]formyl GAR after 30 mins in presence of az...More data for this Ligand-Target Pair
Affinity DataIC50: 780nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair