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Found 9 Enz. Inhib. hit(s) with Target = 'Trifunctional purine biosynthetic protein adenosine-3' and Ligand = 'BDBM22590'
LigandPNGBDBM22590((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...)
Affinity DataKi:  0.000120nMAssay Description:Inhibitory activity against glycinamide ribonucleotide formyltransferase (GARFT) from L1210 murine leukemic cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM22590((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...)
Affinity DataKi:  6nMAssay Description:Inhibition of GARFTase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM22590((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...)
Affinity DataKi:  60nM ΔG°:  -41.4kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM22590((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...)
Affinity DataKi:  60nM ΔG°:  -41.4kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM22590((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...)
Affinity DataKi:  60nMAssay Description:Tested in vitro for its inhibition of trifunctional glycinamide ribonucleotide formyltransferase (GARFT) isolated from murine L1210 leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM22590((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...)
Affinity DataKi:  120nMAssay Description:Tested for the inhibition of trifunctional Glycinamide ribonucleotide formyltransferase isolated from murine L1210 cells.More data for this Ligand-Target Pair
In DepthDetails Article
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM22590((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...)
Affinity DataKi:  130nMAssay Description:Tested for the inhibition of recombinant human monofunctional Glycinamide ribonucleotide formyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM22590((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...)
Affinity DataIC50:  14nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of incorporation of [14C]glycine into [14C]formyl GAR after 30 mins in presence of az...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM22590((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...)
Affinity DataIC50:  780nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed