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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tryptophan 5-hydroxylase 1' and Ligand = 'BDBM50145635'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tryptophan 5-hydroxylase 1


(Homo sapiens (Human))
BDBM50145635
PNG
(CHEMBL3764206)
Show SMILES Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(N)n1)N1CCN(C[C@H](N)C(O)=O)CC1)C(F)(F)F
Show InChI InChI=1/C23H26ClF3N8O3/c1-13-4-5-35(32-13)17-10-14(24)2-3-15(17)20(23(25,26)27)38-19-11-18(30-22(29)31-19)34-8-6-33(7-9-34)12-16(28)21(36)37/h2-5,10-11,16,20H,6-9,12,28H2,1H3,(H,36,37)(H2,29,30,31)/t16-,20+/s2
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Similars

Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Karos Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Bioorg Med Chem Lett 26: 1124-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.064
BindingDB Entry DOI: 10.7270/Q2WD42DJ
More data for this
Ligand-Target Pair