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Found 4 Enz. Inhib. hit(s) with Target = 'Tryptophan 5-hydroxylase 1' and Ligand = 'BDBM50145648'
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145648(LP-778902 | LX1032 | LX1606 | Telotristat | Xermel...)
Affinity DataIC50:  16nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145648(LP-778902 | LX1032 | LX1606 | Telotristat | Xermel...)
Affinity DataIC50:  16nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145648(LP-778902 | LX1032 | LX1606 | Telotristat | Xermel...)
Affinity DataIC50:  64nMAssay Description:Inhibition of Tryptophan hydroxylase 1 (unknown origin) incubated for 4 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145648(LP-778902 | LX1032 | LX1606 | Telotristat | Xermel...)
Affinity DataIC50:  770nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In DepthDetails PubMed