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Found 3 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1' and Ligand = 'BDBM185700'
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Intervet

US Patent
LigandPNGBDBM185700(US10875847, Compound Oclacitinib | US9161939, 1a |...)
Affinity DataIC50:  3.40nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Intervet

US Patent
LigandPNGBDBM185700(US10875847, Compound Oclacitinib | US9161939, 1a |...)
Affinity DataIC50:  9.53nMpH: 7.4Assay Description:Methods: A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK-2 and JAK-3) or the IRS-1 peptide (JAK-1 and Tyk...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Intervet

US Patent
LigandPNGBDBM185700(US10875847, Compound Oclacitinib | US9161939, 1a |...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant JAK1 (852 to 1142 residues) by Z-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed