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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM255020'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM255020
PNG
(US9475813, 25)
Show SMILES FC(F)(F)CNC[C@H]1CC[C@@H](CC1)N1CN(CC2CC2)C(=O)c2cnc3[nH]ccc3c12
Show InChI InChI=1/C22H28F3N5O/c23-22(24,25)12-26-9-14-3-5-16(6-4-14)30-13-29(11-15-1-2-15)21(31)18-10-28-20-17(19(18)30)7-8-27-20/h7-8,10,14-16,26H,1-6,9,11-13H2,(H,27,28)/t14-,16-
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PC cid
PC sid
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US Patent
n/an/a 27n/an/an/an/an/an/a



Nissan Chemical Industries, Ltd

US Patent


Assay Description
The inhibitory activity of the compounds of the present invention against JAK was measured.The respective enzymes (JAK1, JAK2, JAK3 and Tyk2) were pu...


US Patent US9475813 (2016)


BindingDB Entry DOI: 10.7270/Q2PC31BN
More data for this
Ligand-Target Pair