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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Kit (Kit)(D816V)' and Ligand = 'BDBM175689'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175689
PNG
(US9688680, 234)
Show SMILES CC[C@H](NC(=O)C1(C)CN(C1)c1ncnn2cc(cc12)-c1cnn2CCCc12)c1ccc(Cl)cc1
Show InChI InChI=1/C26H28ClN7O/c1-3-21(17-6-8-19(27)9-7-17)31-25(35)26(2)14-32(15-26)24-23-11-18(13-34(23)30-16-28-24)20-12-29-33-10-4-5-22(20)33/h6-9,11-13,16,21H,3-5,10,14-15H2,1-2H3,(H,31,35)/t21-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair