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Found 6 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM100348'
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100348(US10533001, Example Table 9a.1 | US11414410, Table...)
Affinity DataIC50:  55nMAssay Description:SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100348(US10533001, Example Table 9a.1 | US11414410, Table...)
Affinity DataIC50:  55nMAssay Description:Syk and JAK: The activity of a specified compound as an inhibitor of a JAK kinase may be assessed in vitro or in vivo. In some embodiments, the activ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100348(US10533001, Example Table 9a.1 | US11414410, Table...)
Affinity DataIC50:  55nMAssay Description:The kinase reaction is performed in a black U-bottom 96-well microtitre plate. The final reaction volume is 50 μL and contains a final concentra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100348(US10533001, Example Table 9a.1 | US11414410, Table...)
Affinity DataKd:  98nMAssay Description:Syk and JAK: The activity of a specified compound as an inhibitor of a JAK kinase may be assessed in vitro or in vivo. In some embodiments, the activ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100348(US10533001, Example Table 9a.1 | US11414410, Table...)
Affinity DataKd:  98nMAssay Description:This assay is an ATP-site dependent competition binding assay in which human kinases of interest are fused to a proprietary tag (T7 bacteriophage). T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100348(US10533001, Example Table 9a.1 | US11414410, Table...)
Affinity DataKd:  98nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
In DepthDetails US Patent