BindingDB PrimarySearch

Found 9 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase receptor FLT3' and Ligand = 'BDBM60665'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein kinase receptor FLT3 (Homo sapiens (Human))	BDBM60665 (BDBM50249542 \| US9145414, R406 \| US9212178, R406) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. Curated by ChEMBL					Assay Description Inhibition of Flt3 in human MV411 cells assessed as assessed as proliferation after 72 hrs incubation by spectrophotometry				J Med Chem 57: 3856-73 (2014)
Gilead Sciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3 (Homo sapiens (Human))	BDBM60665 (BDBM50249542 \| US9145414, R406 \| US9212178, R406) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by ChEMBL					Assay Description Binding constant for FLT3(N841I) kinase domain				Nat Biotechnol 29: 1046-51 (2011)
Ambit Biosciences Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3 (Homo sapiens (Human))	BDBM60665 (BDBM50249542 \| US9145414, R406 \| US9212178, R406) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by ChEMBL					Assay Description Binding constant for FLT3(R834Q) kinase domain				Nat Biotechnol 29: 1046-51 (2011)
Ambit Biosciences Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3 (Homo sapiens (Human))	BDBM60665 (BDBM50249542 \| US9145414, R406 \| US9212178, R406) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by ChEMBL					Assay Description Binding constant for FLT3(D835H) kinase domain				Nat Biotechnol 29: 1046-51 (2011)
Ambit Biosciences Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3 (Homo sapiens (Human))	BDBM60665 (BDBM50249542 \| US9145414, R406 \| US9212178, R406) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	0.710	n/a	n/a	n/a	n/a	n/a
Califia Bio Inc. Curated by ChEMBL					Assay Description Binding affinity to human FLT3				J Med Chem 56: 8032-48 (2013)
Califia Bio Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3 (Homo sapiens (Human))	BDBM60665 (BDBM50249542 \| US9145414, R406 \| US9212178, R406) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by ChEMBL					Assay Description Binding constant for FLT3(ITD) kinase domain				Nat Biotechnol 29: 1046-51 (2011)
Ambit Biosciences Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3 (Homo sapiens (Human))	BDBM60665 (BDBM50249542 \| US9145414, R406 \| US9212178, R406) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	0.710	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by ChEMBL					Assay Description Binding constant for FLT3 kinase domain				Nat Biotechnol 29: 1046-51 (2011)
Ambit Biosciences Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3 (Homo sapiens (Human))	BDBM60665 (BDBM50249542 \| US9145414, R406 \| US9212178, R406) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	0.680	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by ChEMBL					Assay Description Binding constant for FLT3(D835Y) kinase domain				Nat Biotechnol 29: 1046-51 (2011)
Ambit Biosciences Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3 (Homo sapiens (Human))	BDBM60665 (BDBM50249542 \| US9145414, R406 \| US9212178, R406) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	0.370	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by ChEMBL					Assay Description Binding constant for FLT3(D835Y) kinase domain				Nat Biotechnol 29: 1046-51 (2011)
Ambit Biosciences Curated by ChEMBL					More data for this Ligand-Target Pair