BindingDB PrimarySearch

Found 95 Enz. Inhib. hit(s) with Target = 'Vascular endothelial growth factor receptor 2' and Ligand = 'BDBM16673'

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

Ki: 0.0210nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 60 mins by activity based 100 fold dilution assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

Ki: 0.120nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 60 mins by ligand displacement based enzyme-inhibitor dilution assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

Ki: 22nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 10 mins by Global fit analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 0.0600nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ULight-4E-BP1 peptide as substrate incubated for 1 hr in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 0.160nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 preincubated for 120 mins in presence of ATP by AlphaScreen analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 0.170nMAssay Description:Inhibition of VEGFR2 (unknown origin) after 1 hr by ADP-Glo reagent based luminescent assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 0.170nMAssay Description:Inhibition of VEGFR-2 (unknown origin) after 1 hrs by ADP-Glo luminescence assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 0.340nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details US Patent DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 0.450nMAssay Description:Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 0.480nMAssay Description:Inhibition of VEGFR-2 (unknown origin) after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 0.480nMAssay Description:Inhibition of VEGFR-2 (unknown origin) after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 0.850nMAssay Description:Inhibition of VEGFR-2 (unknown origin) after 60 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 0.850nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ATP measured luminescence by ADP-Glo Kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 1.10nMAssay Description:Inhibition of VEGFR2 (unknown origin) after 30 mins by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 1.20nMAssay Description:Inhibition of VEGFR-2 (unknown origin) assessed as ATP level by luminescence analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 1.30nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly E4Y1 substrate after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 1.40nMAssay Description:Inhibition of KDR (unknown origin) incubated for 1 hr assessed as luminescence changes using ATP by ADP-Glo Kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 3nMAssay Description:Inhibition of recombinant GST-tagged VEGFR2 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 3.10nMAssay Description:Inhibition of VEGFR-2 (unknown origin) incubated for 60 mins by Kinase-Glo luminescent kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 3.20nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 6.20nMAssay Description:Inhibition of human N-terminal His-tagged phosphorylated VEGFR2 preincubated for 120 mins in presence of ATP by AlphaScreen analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 10nMAssay Description:Inhibition of human VEGFR-2 preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 11.1nMT: 2°CAssay Description:Experimental Procedures(1) Kinase reaction substrate Poly(Glu, Tyr, 4:1) was diluted to 20 μg/ml with potassium ion-free PBS, and enzyme labeled pla...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details US Patent DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 13nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Mus musculus)
Bayer Pharmaceuticals

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 15nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 15nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Mus musculus)
Bayer Pharmaceuticals

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 15nMAssay Description:Inhibition of mouse FLK1 (785 to 1367 residues) expressed in sf9 cells after 1.5 to 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 18nMAssay Description:Inhibition of recombinant human His-tagged VEGFR2 cytoplasmic domain (789 to 1356 residues) expressed in baculovirus expression system by Z'-Lyte ass...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 19nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 20nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 21nMAssay Description:Inhibition of VEGFR2 (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 22nMAssay Description:Inhibition of recombinant VEGFR2 using poly(Glu,Tyr)4 as substrate assessed as inhibition of [33P]Phosphate incorporation into substrate after 80 min...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 23nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 in presence of ATP measured without preincubation by AlphaScreen analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 26nMAssay Description:Inhibition of VEGFR2 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate measured after 1 hr in presence of ATP by spectrophotometric analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 28nMAssay Description:Inhibition of VEGFR2 (unknown origin) incubated for 10 mins followed by kinase substrate addition and measured after 30 mins by caliper mobility shif...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 30nMAssay Description:Inhibition of human VEGFR-2 after 2.5 hrs by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 38nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly (Glu, Tyr) 4:1 as substrate preincubated with substrate followed by enzyme challenge for 1 hr by ELI...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 42nMAssay Description:Inhibition of recombinant GST-tagged VEGFR2 kinase domain (V789 to V1356) (unknown origin) expressed in insect Sf9 cells using polyGlu4:Tyr peptide a...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 46nMAssay Description:Inhibition of VEGFR2 (unknown origin) using biotin substrate incubated for 1 hr by HTRF methodMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 51nMAssay Description:Inhibition of VEGFR-2 (unknown origin) by using poly (Glu:Tyr 4:1) as substrate measured after 45 mins by Kinase-Glo max based microplate readerMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 59nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 68nMAssay Description:Inhibition of VEGFR2 (unknown origin) using FAM-labelled peptide as substrate pretreated for 10 mins followed by substrate addition measured after 30...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 72nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged VEGFR-2 (unknown origin) using FL-Peptide 22 as substrate after 90 mins by mobility shift assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 80nMAssay Description:Inhibition of VEGFR-2 (unknown origin) relative to controlMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 89.6nMAssay Description:Kinase Enzymatic step assay Control (10 μL) Sample Negative Positive Compound 4 μL 4 μL 2.5% 4 μL 2.5% DMSO/kinase DMSO/kinase bu...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details US Patent DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 90nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 90nMAssay Description:Inhibition of VEGFR2 (unknown origin) by [33P]radiolabeled methodMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 90nMAssay Description:Inhibition of human recombinant VEGFR2 incubated for 1 hr using [gamma-32P]ATP by top count assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 90nMAssay Description:Inhibition of human VEGFR2 after 1.5 to 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 90nMAssay Description:Inhibition of recombinant human VEGFR-2 expressed in Spodoptera frugiperda cells after 5 mins by using biotinylated poly-GluTyr (4:1) as substrate by...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Displayed 1 to 50 (of 95 total ) | Next | Last >>

Filter my 95 hits

Targets 1▿
- Vascular endothelial growth factor receptor 2 95
Publications 50▿
- Bioorg Med Chem 19: 5342-51 (2011) 7
- Eur J Med Chem 163: 37-53 (2019) 2
- J Med Chem 61: 140-157 (2018) 2
- Eur J Med Chem 107: 165-79 (2016) 2
- Eur J Med Chem 168: 315-329 (2019) 2
- J Med Chem 56: 1641-55 (2013) 2
- Proc Natl Acad Sci U S A 104: 19936-41 (2007) 2
- Cancer Res 64: 7099-109 (2004) 2
- J Med Chem 61: 5073-5092 (2018) 2
- Bioorg Med Chem Lett 36: (2021) 1
- Eur J Med Chem 200: (2020) 1
- Bioorg Med Chem Lett 22: 4654-9 (2012) 1
- Eur J Med Chem 45: 5420-7 (2010) 1
- Bioorg Med Chem Lett 26: 5450-5454 (2016) 1
- Eur J Med Chem 103: 80-90 (2015) 1
- Bioorg Med Chem Lett 28: 1464-1470 (2018) 1
- Eur J Med Chem 179: 707-722 (2019) 1
- Eur J Med Chem 162: 147-160 (2019) 1
- Eur J Med Chem 100: 151-61 (2015) 1
- US Patent US9902709 (2018) 1
- Bioorg Med Chem 27: (2019) 1
- Bioorg Med Chem 24: 6166-6173 (2016) 1
- Eur J Med Chem 109: 371-9 (2016) 1
- Bioorg Med Chem 24: 750-8 (2016) 1
- Bioorg Med Chem 26: 2381-2391 (2018) 1
- Bioorg Med Chem Lett 23: 2962-7 (2013) 1
- Eur J Med Chem 113: 50-62 (2016) 1
- Nat Biotechnol 23: 329-36 (2005) 1
- Nat Biotechnol 29: 1046-51 (2011) 1
- Bioorg Med Chem 19: 4173-82 (2011) 1
- PubChem Bioassay (2008) 1
- Eur J Med Chem 179: 147-165 (2019) 1
- US Patent US9469639 (2016) 1
- RSC Med Chem 13: 1064-1076 (2022) 1
- Eur J Med Chem 163: 1-9 (2019) 1
- Eur J Med Chem 127: 275-285 (2017) 1
- Eur J Med Chem 164: 440-447 (2019) 1
- Bioorg Med Chem 25: 5754-5763 (2017) 1
- Eur J Med Chem 72: 146-59 (2014) 1
- Bioorg Med Chem 22: 277-84 (2014) 1
- Bioorg Med Chem 24: 179-90 (2016) 1
- Eur J Med Chem 108: 495-504 (2016) 1
- Bioorg Med Chem 23: 3228-36 (2015) 1
- Bioorg Med Chem 46: (2021) 1
- Eur J Med Chem 93: 523-38 (2015) 1
- Bioorg Med Chem 50: (2021) 1
- Bioorg Med Chem 28: (2020) 1
- Nat Biotechnol 26: 127-32 (2008) 1
- Eur J Med Chem 53: 254-63 (2012) 1
- Bioorg Med Chem 23: 6497-509 (2015) 1
- ...
Institutions 32▿
- Takeda Pharmaceutical 7
- Xi'An Jiaotong University 5
- Ambit Biosciences 4
- China Pharmaceutical University 4
- Jiangxi Science & Technology Normal University 3
- Mansoura University 3
- National Health Research Institutes 3
- The First Affiliated Hospital Of Xi'An Jiaotong University 3
- Sichuan University 3
- Kafrelsheikh University 3
- Bayer Pharmaceuticals 2
- University Of South Australia 2
- Harvard Medical School 2
- Cairo University 2
- Egyptian Russian University 1
- Peking University Founder Group 1
- Technische Universit£T Braunschweig 1
- Beijing Normal University 1
- Universidade Do Minho 1
- Konkuk University 1
- Radiant Pharma & Tech. 1
- Comenius University 1
- Shenyang Pharmaceutical University 1
- Yantai University 1
- Mahidol University 1
- Taipei Medical University 1
- King Saud University 1
- National Institute Of Pharmaceutical Education And Research (Niper) 1
- National Center For Radiation Research And Technology (Ncrrt) 1
- National Research Centre 1
- Yunnan University 1
- University Shihezi 1
- ...
Affinity: 0.021 to 2.6E+3 nM▿
- Ki 3
- IC50 84
- Kd 7
- EC50 1
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1